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The mission of the Genomics and Translational Bioinformatics Working Group (Gen-TBI, formerly the Genomics Working Group) is to facilitate communication, collaboration, training, and networking for researchers working at the interfaces between bio-molecular and clinical data in order to advance the clinical use of genomics data through TBI, thereby furthering the practice of precision medicine.


The Genomics and Translational Bioinformatics Working Group focuses on opportunities in biomedical informatics that arise from the storage, retrieval, analysis, interpretation, and dissemination of molecular information in translational research and in the clinical setting.

Gen-TBI areas of interest include, but are not limited to:

  • Improving interoperability between clinical and molecular databases
  • Enhancing electronic medical record systems to support molecular information
  • Developing clinical decision support tools that utilize molecular information
  • Modeling and visualizing the molecular basis of disease and disease risk
  • Evaluating existing standards, identifying gaps, and making recommendations
  • Personalized and precision medicine
  • Disease reclassification based on underlying molecular mechanisms
  • Supporting drug development and discovery
  • Molecular diagnostics and prognostics
  • Developing methods utilizing omics and clinical data for discovery

Working Group activities

Past, Present, and Future

  • Working group calls
  • Face to face meetings at the fall Annual Symposium and the spring Summits
  • Webinars
  • Journal club
  • Collaboration with groups both inside and outside AMIA
  • Identification and dissemination of relevant funding opportunities
  • Position papers, white papers on policy issues (e.g., privacy, return of results)
  • Industry-academic collaborations

Related Working Groups

  • Knowledge discovery and data mining
  • Knowledge representation and semantics
  • Clinical research informatics
  • Pharmacoinformatics
  • Ethical, Legal, and Social Issues
  • Clinical Decision Support


Profile image for Zhongming Zhao, PhD

Zhongming Zhao, PhD

Chair 2023-2024
University of Texas Health Science Center at Houston
Profile image for Nephi Walton, MD, MS, FACMG

Nephi Walton, MD, MS, FACMG

Past Chair 2023
Clinical Geneticist
University of Utah