The Shared Health Research Information Network (SHRINE): a prototype federated query tool for clinical data repositories.
The authors developed a prototype Shared Health Research Information Network (SHRINE) to identify the technical, regulatory, and political challenges of creating a federated query tool for clinical data repositories. Separate Institutional Review Boards (IRBs) at Harvard's three largest affiliated health centers approved use of their data, and the Harvard Medical School IRB approved building a Query Aggregator Interface that can simultaneously send queries to each hospital and display aggregate counts [...]
Author(s): Weber, Griffin M, Murphy, Shawn N, McMurry, Andrew J, Macfadden, Douglas, Nigrin, Daniel J, Churchill, Susanne, Kohane, Isaac S
DOI: 10.1197/jamia.M3191