HUGO: Hierarchical mUlti-reference Genome cOmpression for aligned reads.
Short-read sequencing is becoming the standard of practice for the study of structural variants associated with disease. However, with the growth of sequence data largely surpassing reasonable storage capability, the biomedical community is challenged with the management, transfer, archiving, and storage of sequence data.
Author(s): Li, Pinghao, Jiang, Xiaoqian, Wang, Shuang, Kim, Jihoon, Xiong, Hongkai, Ohno-Machado, Lucila
DOI: 10.1136/amiajnl-2013-002147