Unsupervised machine learning and prognostic factors of survival in chronic lymphocytic leukemia.
Unsupervised machine learning approaches hold promise for large-scale clinical data. However, the heterogeneity of clinical data raises new methodological challenges in feature selection, choosing a distance metric that captures biological meaning, and visualization. We hypothesized that clustering could discover prognostic groups from patients with chronic lymphocytic leukemia, a disease that provides biological validation through well-understood outcomes.
Author(s): Coombes, Caitlin E, Abrams, Zachary B, Li, Suli, Abruzzo, Lynne V, Coombes, Kevin R
DOI: 10.1093/jamia/ocaa060