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Knowledge Representation furthers research on formalisms and tools for semantically precise and computable knowledge representation in relation to biomedicine.

Knowledge Discovery and Data Mining focuses on the process of extracting meaningful patterns from biomedical data (knowledge discovery), using automated computational and statistical tools and techniques on large datasets (data mining).

The goals of the AMIA LHS-WG are to build a community of LHS practitioners and researchers in AMIA, foster LHS research and applications, and establish connections among the group from different scientific backgrounds including outside of informatics, and countries.

MHI-WG aims to promote and facilitate opportunities to develop and apply informatics methods and approaches in the context of mental health research and care.

Nursing Informatics is the "science and practice (that) integrates nursing, its information and knowledge, with management of information and communication technologies to promote the health of people, families, and communities worldwide."

The mission of the People and Organizational Issues-Evaluation (POI-Eval) Working Group is to study the interactions between people and technology, including designing, implementing, evaluating, and optimizing safe and usable health information systems and technology.

The Pharmacy Informatics Working group is comprised of AMIA members who are interested in the intersection of informatics, technology and medication management. It is our intention to initiate innovation and patient safety at the nexus of informatics, technology, and medication management for efficient, beneficial patient health care.

Public Health Informatics is the application of informatics in areas of public health, including surveillance, reporting, and health promotion.

AMIA's Student Working Group provides a forum in which informatics students can share their educational experiences and viewpoints, as well as information about career and educational opportunities.

The Surgical and Procedural Informatics Working Group serves as the academic home for professionals focused on informatics, idea exchange, and collaboration within surgical and procedural contexts.