Physiological foundation modeling for subclinical disease assessment: a prospective pilot.
Clinical studies struggle to locate the right patients, in part because many remain undiagnosed or lack relevant labels. We develop and prospectively test a physiology-based patient representation ("Bioprofile") to evaluate whether it can reduce the number of individuals who must be screened and enable more precise targeting of candidates for steatotic liver disease studies.
Author(s): Yuan, William, Xu, Shiwei, Dionisi, Sara, von Herrmann, Katharine, Frederick-Dyer, Kate, Cheung-Flynn, Joyce, Kennedy, Caleb, Flynn, Charles R, Lipnick, Scott
DOI: 10.1093/jamiaopen/ooag002