Implementing integrated genomic risk assessments for breast cancer: lessons learned from the Electronic Medical Records and Genomics study.
To implementation an automated multi-institutional pipeline that delivers breast-cancer risk integrated with polygenic risk scores, monogenic variants, family history, and clinical factors, emphasizing operational challenges and their solutions.
Author(s): Liu, Cong, Crew, Katherine D, Morse, Jennifer, Linder, Jodell E, Antoniou, Antonis C, Carver, Tim, Cortopassi, Josh, Peterson, Josh F, Ta, Casey N, Hoell, Christin, Prows, Cynthia, Kenny, Eimear E, Miller, Emily, Perez, Emma, Jarvik, Gail P, Bland, Harris T, Odgis, Jacqueline A, Mittendorf, Kathleen F, Bonini, Katherine E, McGuffin, Kyle, Kottyan, Leah C, Maradik, Mary, Limdi, Nita, Abul-Husn, Noura S, Marathe, Priya N, Suckiel, Sabrina A, Aguilar, Sienna, Lewis, Toni J, Wei, Wei-Qi, Luo, Yuan, Freimuth, Robert R, Hakonarson, Hakon, Weng, Chunhua, Chung, Wendy K, Wiesner, Georgia L
DOI: 10.1093/jamiaopen/ooaf113