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Sudden changes in health care utilization during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic may have impacted the performance of clinical predictive models that were trained prior to the pandemic. In this study, we evaluated the performance over time of a machine learning, electronic health record-based mortality prediction algorithm currently used in clinical practice to identify patients with cancer who may benefit from early advance care planning conversations [...]

Machine learning (ML) has the potential to facilitate "continual learning" in medicine, in which an ML system continues to evolve in response to exposure to new data over time, even after being deployed in a clinical setting. In this article, we provide a tutorial on the range of ethical issues raised by the use of such "adaptive" ML systems in medicine that have, thus far, been neglected in the literature.

This study aims to develop a convolutional neural network-based learning framework called domain knowledge-infused convolutional neural network (DK-CNN) for retrieving clinically similar patient and to personalize the prediction of macrovascular complication using the retrieved patients.

To develop an automated deidentification pipeline for radiology reports that detect protected health information (PHI) entities and replaces them with realistic surrogates "hiding in plain sight."

The rapidly growing body of communications during the COVID-19 pandemic posed a challenge to information seekers, who struggled to find answers to their specific and changing information needs. We designed a Question Answering (QA) system capable of answering ad-hoc questions about the COVID-19 disease, its causal virus SARS-CoV-2, and the recommended response to the pandemic.

To summarize the research literature evaluating automated methods for early detection of safety problems with health information technology (HIT).

To access the accuracy of the Logical Observation Identifiers Names and Codes (LOINC) mapping to local laboratory test codes that is crucial to data integration across time and healthcare systems.

To identify and characterize clinical subgroups of hospitalized Coronavirus Disease 2019 (COVID-19) patients.

Patient phenotype definitions based on terminologies are required for the computational use of electronic health records. Within UK primary care research databases, such definitions have typically been represented as flat lists of Read terms, but Systematized Nomenclature of Medicine-Clinical Terms (SNOMED CT) (a widely employed international reference terminology) enables the use of relationships between concepts, which could facilitate the phenotyping process. We implemented SNOMED CT-based phenotyping approaches and investigated their [...]

Electronic (e)-phenotype specification by noninformaticist investigators remains a challenge. Although validation of each patient returned by e-phenotype could ensure accuracy of cohort representation, this approach is not practical. Understanding the factors leading to successful e-phenotype specification may reveal generalizable strategies leading to better results.