Applying knowledge-anchored hypothesis discovery methods to advance clinical and translational research: the OAMiner project.
The conduct of clinical and translational research regularly involves the use of a variety of heterogeneous and large-scale data resources. Scalable methods for the integrative analysis of such resources, particularly when attempting to leverage computable domain knowledge in order to generate actionable hypotheses in a high-throughput manner, remain an open area of research. In this report, we describe both a generalizable design pattern for such integrative knowledge-anchored hypothesis discovery operations [...]
Author(s): Payne, Philip R O, Jackson, Rebecca D, Best, Thomas M, Borlawsky, Tara B, Lai, Albert M, James, Stephen, Gurcan, Metin N
DOI: 10.1136/amiajnl-2011-000736