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To test the feasibility of using text mining to depict meaningfully the experience of pain in patients with metastatic prostate cancer, to identify novel pain phenotypes, and to propose methods for longitudinal visualization of pain status.

Implementation of Computerized Provider Order Entry (CPOE) has many potential advantages. Despite the potential benefits of CPOE, several attempts to implement CPOE systems have failed or met with high levels of user resistance. Implementation of CPOE can fail or meet high levels of user resistance for a variety of reasons, including lack of attention to users' needs and the significant workflow changes required by CPOE. User satisfaction is a critical [...]

Point-of-care information needs are common and frequently unmet. One solution to this problem is the use of Infobuttons, which are context-sensitive links from electronic health records (EHR) to knowledge resources, sometimes involving an intermediate broker known as an Infobutton Manager. Health Level Seven (HL7) has developed the Context-Aware Knowledge Retrieval (Infobutton) standard to standardize the integration between EHR systems and knowledge resources. While the standard specifies a set of context [...]

Word sense disambiguation (WSD) methods automatically assign an unambiguous concept to an ambiguous term based on context, and are important to many text-processing tasks. In this study we developed and evaluated a knowledge-based WSD method that uses semantic similarity measures derived from the Unified Medical Language System (UMLS) and evaluated the contribution of WSD to clinical text classification.

Ascertainment of potential subjects has been a longstanding problem in clinical research. Various methods have been proposed, including using data in electronic health records. However, these methods typically suffer from scaling effects-some methods work well for large cohorts; others work for small cohorts only.

To build an effective co-reference resolution system tailored to the biomedical domain.

The term informatics is currently enveloped in chaos. One way to clarify the meaning of informatics is to identify the competencies associated with training in the field, but this approach can conceal the whole that the competencies atomistically describe. This work takes a different approach by offering three higher-level visions of what characterizes the field, viewing informatics as: (1) cross-training between basic informational sciences and an application domain, (2) the [...]

We present SHARE, a new system for statistical health information release with differential privacy. We present two case studies that evaluate the software on real medical datasets and demonstrate the feasibility and utility of applying the differential privacy framework on biomedical data.