PIE: A prior knowledge guided integrated likelihood estimation method for bias reduction in association studies using electronic health records data.
This study proposes a novel Prior knowledge guided Integrated likelihood Estimation (PIE) method to correct bias in estimations of associations due to misclassification of electronic health record (EHR)-derived binary phenotypes, and evaluates the performance of the proposed method by comparing it to 2 methods in common practice.
Author(s): Huang, Jing, Duan, Rui, Hubbard, Rebecca A, Wu, Yonghui, Moore, Jason H, Xu, Hua, Chen, Yong
DOI: 10.1093/jamia/ocx137