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The successful integration of Machine Learning (ML) models into clinical practice remains limited, as they often lack the standardized, quantifiable risk measures essential for clinical workflows. This study, therefore, aims to demonstrate the Unified Auto Clinical Scores (Uni-ACS) method as a means to translate ML predictions into interpretable biostatistical formats, a translation critical for clinical adoption and alignment with evidence-based practice guidelines.

To describe considerations for integration of human and artificial intelligence for creating a postmarketing surveillance system capable of timely and reliably identifying causal effects of medications on safety endpoints.

Distributed Research Networks (DRNs) offer significant opportunities for collaborative multi-site research and have significantly advanced healthcare research based on clinical observational data. However, generating high-quality real-world evidence using fit-for-use data from multi-site studies faces important challenges, including biases associated with various types of heterogeneity within and across sites and data sharing difficulties. Over the last 10 years, Privacy-Preserving Distributed Algorithms (PDA) have been developed and utilized in numerous national and [...]

To argue that diagnostic and predictive AI should be evaluated by both classification performance and the downstream work their outputs create.

We examine how hospital characteristics relate to clinical and operational artificial intelligence (AI) adoption and implementation stages and characterize AI deserts and spatial clustering patterns to highlight place-based AI access gaps among United States (US) hospitals.

Artificial intelligence (A.I.) technologies are increasingly deployed across clinical care, yet reimbursement remains a major barrier to sustainable adoption. The Centers for Medicare & Medicaid Services (CMS) currently reimburses A.I.-enabled technologies through a fragmented set of procedural codes, add-on payments, and legacy payment models, none of which were designed to support the complexity or workflow integration of clinical A.I. This article examines how existing CMS reimbursement pathways for A.I. function [...]

This study explores patient motivations and preferences for sharing medical data with researchers using the iAgree platform. We examine how study characteristics, including data type requested and data-sharing arrangements, influence consent decisions, and assess the role of demographic factors, privacy concerns, and perceived benefits in shaping data-sharing behavior.

The automation of medical report generation using large language models (LLMs) could significantly reduce physicians' documentation burden while enhancing healthcare efficiency. However, the misuse of generative artificial intelligence in medical reporting can lead to important safety risks for patients. We addressed 2 questions: (1) What is the quality of medical reports generated by LLMs in English and French? and (2) Can we distinguish between human-written and LLM-generated medical reports?

To evaluate if a single-subject study (S3) design, utilizing paired transcriptome samples from the same patient (eg, "sepsis" vs "recovered"), can replicate transcriptomic signatures from small case-control studies, addressing challenges in patient accrual for rare or sub-stratified diseases.