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Over a 31-year span as Director of the US National Library of Medicine (NLM), Donald A.B. Lindberg, MD, and his extraordinary NLM colleagues fundamentally changed the field of biomedical and health informatics-with a resulting impact on biomedicine that is much broader than its influence on any single subfield. This article provides substance to bolster that claim. The review is based in part on the informatics section of a new book [...]

We address a first step toward using social media data to supplement current efforts in monitoring population-level medication nonadherence: detecting changes to medication treatment. Medication treatment changes, like changes to dosage or to frequency of intake, that are not overseen by physicians are, by that, nonadherence to medication. Despite the consequences, including worsening health conditions or death, 50% of patients are estimated to not take medications as indicated. Current methods [...]

While the professional version of the Mobile App Rating Scale (MARS) has already been translated, and validated into the Spanish language, its user-centered counterpart has not yet been adapted. Furthermore, no other similar tools exist in the Spanish language. The aim of this paper is to adapt and validate User Version of the MARS (uMARS) into the Spanish language.

Social determinants of health (SDoH) are nonclinical dispositions that impact patient health risks and clinical outcomes. Leveraging SDoH in clinical decision-making can potentially improve diagnosis, treatment planning, and patient outcomes. Despite increased interest in capturing SDoH in electronic health records (EHRs), such information is typically locked in unstructured clinical notes. Natural language processing (NLP) is the key technology to extract SDoH information from clinical text and expand its utility in [...]

Injured extremities commonly need to be immobilized by casts to allow proper healing. We propose a method to suppress cast superimpositions in pediatric wrist radiographs based on the cycle generative adversarial network (CycleGAN) model. We retrospectively reviewed unpaired pediatric wrist radiographs (n = 9672) and sampled them into 2 equal groups, with and without cast. The test subset consisted of 718 radiographs with cast. We evaluated different quadratic input sizes (256, 512 [...]

Making EHR Data More Available for Research and Public Health (MedMorph) is a Centers for Disease Control and Prevention-led initiative developing and demonstrating a reference architecture (RA) and implementation, including Health Level Seven International Fast Healthcare Interoperability Resources (HL7 FHIR) implementation guides (IGs), describing how to leverage FHIR for aligned research and public health access to clinical data for automated data exchange. MedMorph engaged a technical expert panel of more [...]

Large amounts of health data are becoming available for biomedical research. Synthesizing information across databases may capture more comprehensive pictures of patient health and enable novel research studies. When no gold standard mappings between patient records are available, researchers may probabilistically link records from separate databases and analyze the linked data. However, previous linked data inference methods are constrained to certain linkage settings and exhibit low power. Here, we present [...]

To examine the effectiveness of event notification service (ENS) alerts on health care delivery processes and outcomes for older adults.

We identified challenges and solutions to using electronic health record (EHR) systems for the design and conduct of pragmatic research.

Hospital capacity management depends on accurate real-time estimates of hospital-wide discharges. Estimation by a clinician requires an excessively large amount of effort and, even when attempted, accuracy in forecasting next-day patient-level discharge is poor. This study aims to support next-day discharge predictions with machine learning by incorporating electronic health record (EHR) audit log data, a resource that captures EHR users' granular interactions with patients' records by communicating various semantics and [...]