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The degree to which deployed artificial intelligence-based deterioration prediction algorithms (AI-DPA) differ in their development, the reasons for these differences, and how this may impact their performance remains unclear. Our primary objective was to identify design factors and associated decisions related to the development of AI-DPA and highlight deficits that require further research.

Generative AI, particularly large language models (LLMs), holds great potential for improving patient care and operational efficiency in healthcare. However, the use of LLMs is complicated by regulatory concerns around data security and patient privacy. This study aimed to develop and evaluate a secure infrastructure that allows researchers to safely leverage LLMs in healthcare while ensuring HIPAA compliance and promoting equitable AI.

Brief hospital course (BHC) summaries are clinical documents that summarize a patient's hospital stay. While large language models (LLMs) depict remarkable capabilities in automating real-world tasks, their capabilities for healthcare applications such as synthesizing BHCs from clinical notes have not been shown. We introduce a novel preprocessed dataset, the MIMIC-IV-BHC, encapsulating clinical note and BHC pairs to adapt LLMs for BHC synthesis. Furthermore, we introduce a benchmark of the summarization [...]

This article describes the implementation of preemptive clinical pharmacogenomics (PGx) testing linked to an automated clinical decision support (CDS) system delivering actionable PGx information to clinicians at the point of care at UCSF Health, a large Academic Medical Center.

To develop an advanced multi-task large language model (LLM) framework for extracting diverse types of information about dietary supplements (DSs) from clinical records.

Machine learning and deep learning are powerful tools for analyzing electronic health records (EHRs) in healthcare research. Although family health history has been recognized as a major predictor for a wide spectrum of diseases, research has so far adopted a limited view of family relations, essentially treating patients as independent samples in the analysis.

We aim to demonstrate the versatility of the All of Us database as an important source of rare and undiagnosed disease (RUD) data, because of its large size and range of data types.

Advances in health informatics rapidly expanded use of big-data analytics and electronic health records (EHR) by clinical researchers seeking to optimize interprofessional ICU team care. This study developed and validated a program for extracting interprofessional teams assigned to each patient each shift from EHR event logs.

Direct electronic access to multiple electronic health record (EHR) systems through patient portals offers a novel avenue for decentralized research. Given the critical value of patient characterization, we sought to compare computable evaluation of health conditions from patient-portal EHR against the traditional self-report.

We developed and validated a large language model (LLM)-assisted system for conducting systematic literature reviews in health technology assessment (HTA) submissions.