Interdisciplinary development and application of computational methods in informatics for clinical applications.
Author(s): Albers, David, Cato, Kenrick, Layton, Anita, Rossetti, Sarah C
DOI: 10.1093/jamia/ocaf209
Author(s): Albers, David, Cato, Kenrick, Layton, Anita, Rossetti, Sarah C
DOI: 10.1093/jamia/ocaf209
The objective of this study is to provide an overview of the current landscape of individualized treatment effects (ITE) estimation, specifically focusing on methodologies proposed for time-series electronic health records (EHRs). We aim to identify gaps in the literature, discuss challenges, and propose future research directions to advance the field of personalized medicine.
Author(s): Ghosheh, Ghadeer O, Gögl, Moritz, Zhu, Tingting
DOI: 10.1093/jamia/ocae323
This study addresses the significant challenges posed by emerging SARS-CoV-2 variants, particularly in developing diagnostics and therapeutics. Drug repurposing is investigated by identifying critical regulatory proteins impacted by the virus, providing rapid and effective therapeutic solutions for better disease management.
Author(s): Bakshi, Abhisek, Gangopadhyay, Kaustav, Basak, Sujit, De, Rajat K, Sengupta, Souvik, Dasgupta, Abhijit
DOI: 10.1093/jamia/ocaf035
Report the development of the patient-centered myAURA application and suite of methods designed to aid epilepsy patients, caregivers, and clinicians in making decisions about self-management and care.
Author(s): Correia, Rion Brattig, Rozum, Jordan C, Cross, Leonard, Felag, Jack, Gallant, Michael, Guo, Ziqi, Herr, Bruce W, Min, Aehong, Sanchez-Valle, Jon, Stungis Rocha, Deborah, Valencia, Alfonso, Wang, Xuan, Börner, Katy, Miller, Wendy, Rocha, Luis M
DOI: 10.1093/jamia/ocaf012
We aimed to develop a highly interpretable and effective, machine learning (ML)-based risk prediction algorithm to predict in-hospital mortality, intubation, and adverse cardiovascular events in patients hospitalized with coronavirus disease 2019 (COVID-19) in Australia (AUS-COVID Score).
Author(s): Sritharan, Hari P, Nguyen, Harrison, van Gaal, William, Kritharides, Leonard, Chow, Clara K, Bhindi, Ravinay, ,
DOI: 10.1093/jamia/ocaf016
A proof-of-concept study aimed at designing and implementing Visual & Interactive Engagement With Electronic Records (VIEWER), a versatile toolkit for visual analytics of clinical data, and systematically evaluating its effectiveness across various clinical applications while gathering feedback for iterative improvements.
Author(s): Wang, Tao, Codling, David, Msosa, Yamiko Joseph, Broadbent, Matthew, Kornblum, Daisy, Polling, Catherine, Searle, Thomas, Delaney-Pope, Claire, Arroyo, Barbara, MacLellan, Stuart, Keddie, Zoe, Docherty, Mary, Roberts, Angus, Stewart, Robert, McGuire, Philip, Dobson, Richard, Harland, Robert
DOI: 10.1093/jamia/ocaf010
To develop a framework that models the impact of electronic health record (EHR) systems on healthcare professionals' well-being and their relationships with patients, using interdisciplinary insights to guide machine learning in identifying value patterns important to healthcare professionals in EHR systems.
Author(s): Cauley, Michael R, Boland, Richard J, Rosenbloom, S Trent
DOI: 10.1093/jamia/ocaf001
This study introduces Smart Imitator (SI), a 2-phase reinforcement learning (RL) solution enhancing personalized treatment policies in healthcare, addressing challenges from imperfect clinician data and complex environments.
Author(s): Perera, Dilruk, Liu, Siqi, See, Kay Choong, Feng, Mengling
DOI: 10.1093/jamia/ocae320
To address the challenges of data heterogeneity and manual feature engineering in clinical predictive modeling, we introduce FHIR-Former, an open-source framework integrating Fast Healthcare Interoperability Resources (FHIR) with large language models (LLMs) to automate and standardize clinical prediction tasks.
Author(s): Engelke, Merlin, Baldini, Giulia, Kleesiek, Jens, Nensa, Felix, Dada, Amin
DOI: 10.1093/jamia/ocaf165
To evaluate the accuracy, computational cost, and portability of a new natural language processing (NLP) method for extracting medication information from clinical narratives.
Author(s): Fabacher, Thibaut, Sauleau, Erik-André, Arcay, Emmanuelle, Faye, Bineta, Alter, Maxime, Chahard, Archia, Miraillet, Nathan, Coulet, Adrien, Névéol, Aurélie
DOI: 10.1093/jamia/ocaf113