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We aimed to demonstrate the importance of establishing best practices in large language model research, using repeat prompting as an illustrative example.

To identify stigmatizing language in obstetric clinical notes using natural language processing (NLP).

The phenome-wide association study (PheWAS) systematically examines the phenotypic spectrum extracted from electronic health records (EHRs) to uncover correlations between phenotypes and exposures. This review explores methodologies, highlights challenges, and outlines future directions for EHR-driven PheWAS.

To develop and validate a machine learning model that helps physician advisors efficiently identify hospital admission denials likely to be overturned on appeal.

The predictive intensive care unit (ICU) scoring system is crucial for predicting patient outcomes, particularly mortality. Traditional scoring systems rely mainly on structured clinical data from electronic health records, which can overlook important clinical information in narratives and images.

Artificial intelligence (AI) technology promises to be a powerful tool in addressing the global health challenges posed by tuberculosis (TB). However, evidence for its real-world impact is lacking, which may hinder safe, responsible adoption. This case study addresses this gap by assessing the technical performance, usability and workflow aspects, and health impact of implementing a commercial AI system (qXR by Qure.ai) to support Australian radiologists in diagnosing pulmonary TB.

Deidentification of personally identifiable information in free-text clinical data is fundamental to making these data broadly available for research. However, there exist gaps in the deidentification landscape with regard to the functionality and flexibility of extant tools, as well as suboptimal tradeoffs between deidentification accuracy and speed. To address these gaps and tradeoffs, we develop a new Python-based deidentification software, pyDeid.

To evaluate large language models (LLMs) for pre-test diagnostic probability estimation and compare their uncertainty estimation performance with a traditional machine learning classifier.

Measurement of health-related social needs (HRSNs) is complex. We sought to develop and validate computable phenotypes (CPs) using structured electronic health record (EHR) data for food insecurity, housing instability, financial insecurity, transportation barriers, and a composite-type measure of these, using human-defined rule-based and machine learning (ML) classifier approaches.

In the general hospital wards, machine learning (ML)-based early warning systems (EWSs) can identify patients at risk of deterioration to facilitate rescue interventions. We assess subpopulation performance of a ML-based EWS on medical and surgical adult patients admitted to general hospital wards.