Search AMIA.org

To develop an unbiased objective for learning automatic coding algorithms from clinical records annotated with only partial relevant International Classification of Diseases codes, as annotation noise in undercoded clinical records used as training data can mislead the learning process of deep neural networks.

Many genetic variants are classified, but many more are variants of uncertain significance (VUS). Clinical observations of patients and their families may provide sufficient evidence to classify VUS. Understanding how long it takes to accumulate sufficient patient data to classify VUS can inform decisions in data sharing, disease management, and functional assay development.

Accurate and rapid phenotyping is a prerequisite to leveraging electronic health records for biomedical research. While early phenotyping relied on rule-based algorithms curated by experts, machine learning (ML) approaches have emerged as an alternative to improve scalability across phenotypes and healthcare settings. This study evaluates ML-based phenotyping with respect to (1) the data sources used, (2) the phenotypes considered, (3) the methods applied, and (4) the reporting and evaluation methods [...]

The rapidly growing body of communications during the COVID-19 pandemic posed a challenge to information seekers, who struggled to find answers to their specific and changing information needs. We designed a Question Answering (QA) system capable of answering ad-hoc questions about the COVID-19 disease, its causal virus SARS-CoV-2, and the recommended response to the pandemic.

To access the accuracy of the Logical Observation Identifiers Names and Codes (LOINC) mapping to local laboratory test codes that is crucial to data integration across time and healthcare systems.

To identify and characterize clinical subgroups of hospitalized Coronavirus Disease 2019 (COVID-19) patients.

Clinical knowledge-enriched transformer models (eg, ClinicalBERT) have state-of-the-art results on clinical natural language processing (NLP) tasks. One of the core limitations of these transformer models is the substantial memory consumption due to their full self-attention mechanism, which leads to the performance degradation in long clinical texts. To overcome this, we propose to leverage long-sequence transformer models (eg, Longformer and BigBird), which extend the maximum input sequence length from 512 to [...]