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The NIH's Bridge2AI Program has funded 4 "new flagship biomedical and behavioral datasets that are properly documented and ready for use with AI [artificial intelligence] or ML [machine learning] technologies" to promote the adoption of AI. This article discusses the challenges and lessons learned in data collection and governance to ensure their responsible use.

This research aimed to design and evaluate a clinician-facing report generated from the SYmptom iNput Clinical (SYNC) system, a digital questionnaire for patients to report Head and Neck Cancer (HNC) symptoms and uses this to calculate a risk score. The research explored how the SYNC system could be integrated into existing hospital workflows.

To evaluate whether large language models (LLMs) can automate chart review to identify tumor necrosis factor inhibitor (TNFi) switching patterns and reasons for switching in a large real-world cohort.

To address algorithmic bias in clinical prediction models related to the timing of diagnosis, we evaluated the efficacy of mixture cure models that integrate time-to-event and binary classification frameworks to predict diagnoses.

Sharing clinical data for research that is both collaborative and privacy-preserving remains a challenge. Differential privacy (DP) offers a solution by introducing noise to query results. Using the PrivateSQL DP platform, this study assesses the resulting utility of differentially private data at different levels of aggregation through analyses of COVID-19 pandemic associations with new cancer diagnosis counts (NCCs).

Critically ill patients are managed with complex medication regimens that require medication management to optimize safety and efficacy. When performed by a critical care pharmacist (CCP), discrete medication management activities are termed medication interventions. The ability to define CCP workflow and intervention timeliness depends on the ability to predict the medication management needs of individual intensive care unit (ICU) patients. The purpose of this study was to develop prediction models [...]

A point-of-care resource is required to support Registered Dietitian Nutritionists (RDNs) in providing comprehensive culturally-tailored nutrition services. This study aims to describe the iterative development and testing of a comprehensive nutrition assessment tool as part of a novel web-based platform to Support Personalized and Inclusive Cuisines in Environments for Healthcare (SPICE-Healthcare).

To address the challenges of data heterogeneity and manual feature engineering in clinical predictive modeling, we introduce FHIR-Former, an open-source framework integrating Fast Healthcare Interoperability Resources (FHIR) with large language models (LLMs) to automate and standardize clinical prediction tasks.

To evaluate the accuracy, computational cost, and portability of a new natural language processing (NLP) method for extracting medication information from clinical narratives.

In medical research and education, generative artificial intelligence/machine learning (AI/ML) models to synthesize artificial medical data can enable the sharing of high-quality data while preserving the privacy of patients. Given that such data is often high-dimensional, a relevant consideration is whether to synthesize the entire dataset when only a task-relevant subset is needed. This study evaluates how the number of variables in training impacts fidelity, utility, and privacy of the [...]