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Claude Opus 4 is a large language model (LLM) that features improved reasoning capabilities and broader contextual understanding compared to earlier versions. Despite the growing use of LLM systems for seeking medical information, structured and simulation-based evaluations of Claude Opus 4's capabilities in diabetes management remain limited, particularly across domains such as patient education, clinical reasoning, and emotional support.

To assess patient attitudes towards ambient artificial intelligence (AI) scribes, including comfort, trust, perceived impact on provider interactions, and willingness for future use, and to examine how sociodemographic, health factors, digital literacy, and privacy concerns shape attitudes.

Real-world evidence (RWE) increasingly informs clinical decisions, yet manual adjustment for confounding limits scalability. Data-adaptive (DA) algorithms for high-dimensional proxy adjustment show promise but have not been systematically compared to investigator-specified (IS) approaches across diverse treatment scenarios. We evaluated whether DA strategies perform comparably to manually curated IS models using claims-based emulations of 15 randomized trials from the RCT-DUPLICATE initiative.

To qualitatively characterize barriers and facilitators to implementing and using an ambient scribe across a large academic medical center, as well as how ambient transcription reshapes clinicians' perceptions of their work.

To address the challenges of data heterogeneity and manual feature engineering in clinical predictive modeling, we introduce FHIR-Former, an open-source framework integrating Fast Healthcare Interoperability Resources (FHIR) with large language models (LLMs) to automate and standardize clinical prediction tasks.

While timely interventions can improve medication adherence, it is challenging to identify which patients are at risk of nonadherence at point-of-care. We aim to develop and validate flexible machine learning (ML) models to predict a continuous measure of adherence to guideline-directed medication therapies (GDMTs) for heart failure (HF).

Patients of different race have different outcomes following renal transplantation. Patients of different race also undergo renal transplantation at different hospitals. We used a novel decentralized multisite approach to quantitatively assess the effect of site of care on racial disparities between non-Hispanic Black (NHB) and non-Hispanic White (NHW) patients in post-transplantation survival times.

Rule-based structured data algorithms and natural language processing (NLP) approaches applied to unstructured clinical notes have limited accuracy and poor generalizability for identifying immunosuppression. Large language models (LLMs) may effectively identify patients with heterogenous types of immunosuppression from unstructured clinical notes. We compared the performance of LLMs applied to unstructured notes for identifying patients with immunosuppressive conditions or immunosuppressive medication use against 2 baselines: (1) structured data algorithms using diagnosis [...]

The objective of this study is to evaluate retrieval-augmented prediction for forecasting hospital length of stay (LOS) following surgery compared to traditional machine learning (ML), standalone large language models (LLMs), and retrieval-augmented generation (RAG) approaches.

To evaluate the accuracy, computational cost, and portability of a new natural language processing (NLP) method for extracting medication information from clinical narratives.