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Computational phenotypes can be used to improve patient selection for observational studies. We sought to derive and validate a computational phenotype for pediatric asthma exacerbation requiring hospitalization.

Despite the increased availability of electronic health records, open-source standardized data collection to facilitate high-resolution data during extracorporeal life support (ECLS) is lacking. This project aimed to assess the Observational Medical Outcomes Partnership Common Data Model (OMOP CDM) for interoperability to store data sufficiently generated in the context of ECLS and to develop a custom data model expansion in case the OMOP CDM proved insufficient.

Early prediction of in-hospital death remains a significant challenge due to the limited availability of structured data during initial admission. Unstructured clinical notes, which often contain important observations and impressions, are an underutilized resource for real-time risk stratification. While leveraging recent advances in large language models (LLMs) is a promising approach to use this unstructured information, the lack of understanding of the uncertainty of LLM predictions, at the patient level [...]

We aimed to (1) quantify changes in discrimination when adding intraoperative data to preoperative data and (2) compare tabular machine learning with feature engineering against a time-aware LSTM-based model.

Emergency department (ED) returns for mental health (MH) conditions pose a substantial burden on healthcare systems. Traditional machine learning (ML) models have shown promise in predicting ED returns but often fall short in clinical interpretability. This study evaluates whether integrating Large Language Models (LLMs) with ML methods can enhance both predictive performance and interpretability.

To facilitate responsible biomedical data sharing, large-scale data harmonization, and cutting-edge artificial intelligence (AI) applications by augmenting controlled-access data dissemination models (DDMs) with Data-derived Identity Verification (DIVe).

Large language models (LLMs) may improve analysis of structured clinical data by enabling natural language (NL) queries. We developed an interactive, PHI-compliant "Text2SQL" chatbot as a proof-of-concept for hepatocellular carcinoma (HCC) research.

Many patients struggle to interpret lab and test results.

Phenotype libraries accelerate health research through the reuse of algorithms. However, multiple libraries exist with differing metadata standards. We describe the integration of libraries using shared conceptual standards to harmonize definitions.

This study evaluated the quality and trustworthiness of large language model (LLM)-generated scientific and plain language summaries (PLS) from clinical oncology literature, focusing on faithfulness (absence of hallucinations), relevance, and readability.