Use of an algorithm for identifying hidden drug–drug interactions in adverse event reports.
Author(s): Gooden, Kyna McCullough, Pan, Xianying, Kawabata, Hugh, Heim, Jean-Marie
DOI: 10.1136/amiajnl-2012-001234
Author(s): Gooden, Kyna McCullough, Pan, Xianying, Kawabata, Hugh, Heim, Jean-Marie
DOI: 10.1136/amiajnl-2012-001234
Patient portal use has been associated with favorable outcomes, but we know less about how patients use and benefit from specific patient portal features.
Author(s): Wade-Vuturo, Ashley E, Mayberry, Lindsay Satterwhite, Osborn, Chandra Y
DOI: 10.1136/amiajnl-2012-001253
Privacy-preserving data publishing addresses the problem of disclosing sensitive data when mining for useful information. Among existing privacy models, ε-differential privacy provides one of the strongest privacy guarantees and makes no assumptions about an adversary's background knowledge. All existing solutions that ensure ε-differential privacy handle the problem of disclosing relational and set-valued data in a privacy-preserving manner separately. In this paper, we propose an algorithm that considers both relational and [...]
Author(s): Mohammed, Noman, Jiang, Xiaoqian, Chen, Rui, Fung, Benjamin C M, Ohno-Machado, Lucila
DOI: 10.1136/amiajnl-2012-001027
The aim of this research was to automate the search of publications concerning adverse drug reactions (ADR) by defining the queries used to search MEDLINE and by determining the required threshold for the number of extracted publications to confirm the drug/event association in the literature.
Author(s): Avillach, Paul, Dufour, Jean-Charles, Diallo, Gayo, Salvo, Francesco, Joubert, Michel, Thiessard, Frantz, Mougin, Fleur, Trifirò, Gianluca, Fourrier-Réglat, Annie, Pariente, Antoine, Fieschi, Marius
DOI: 10.1136/amiajnl-2012-001083
To explore the applicability of a syndromic surveillance method to the early detection of health information technology (HIT) system failures.
Author(s): Ong, Mei-Sing, Magrabi, Farah, Coiera, Enrico
DOI: 10.1136/amiajnl-2012-001144
To evaluate an online disease management system supporting patients with uncontrolled type 2 diabetes.
Author(s): Tang, Paul C, Overhage, J Marc, Chan, Albert Solomon, Brown, Nancy L, Aghighi, Bahar, Entwistle, Martin P, Hui, Siu Lui, Hyde, Shauna M, Klieman, Linda H, Mitchell, Charlotte J, Perkins, Anthony J, Qureshi, Lubna S, Waltimyer, Tanya A, Winters, Leigha J, Young, Charles Y
DOI: 10.1136/amiajnl-2012-001263
Drug-drug interaction (DDI) alerting is an important form of clinical decision support, yet physicians often fail to attend to critical DDI warnings due to alert fatigue. We previously described a model for highlighting patients at high risk of a DDI by enhancing alerts with relevant laboratory data. We sought to evaluate the effect of this model on alert adherence in high-risk patients.
Author(s): Duke, Jon D, Li, Xiaochun, Dexter, Paul
DOI: 10.1136/amiajnl-2012-001073
Medication safety requires that each drug be monitored throughout its market life as early detection of adverse drug reactions (ADRs) can lead to alerts that prevent patient harm. Recently, electronic medical records (EMRs) have emerged as a valuable resource for pharmacovigilance. This study examines the use of retrospective medication orders and inpatient laboratory results documented in the EMR to identify ADRs.
Author(s): Liu, Mei, McPeek Hinz, Eugenia Renne, Matheny, Michael Edwin, Denny, Joshua C, Schildcrout, Jonathan Scott, Miller, Randolph A, Xu, Hua
DOI: 10.1136/amiajnl-2012-001119
Data-mining algorithms that can produce accurate signals of potentially novel adverse drug reactions (ADRs) are a central component of pharmacovigilance. We propose a signal-detection strategy that combines the adverse event reporting system (AERS) of the Food and Drug Administration and electronic health records (EHRs) by requiring signaling in both sources. We claim that this approach leads to improved accuracy of signal detection when the goal is to produce a highly [...]
Author(s): Harpaz, Rave, Vilar, Santiago, Dumouchel, William, Salmasian, Hojjat, Haerian, Krystl, Shah, Nigam H, Chase, Herbert S, Friedman, Carol
DOI: 10.1136/amiajnl-2012-000930
This paper summarizes much of the research that is applicable to the design of auditory alarms in a medical context. It also summarizes research that demonstrates that false alarm rates are unacceptably high, meaning that the proper application of auditory alarm design principles are compromised.
Author(s): Edworthy, Judy
DOI: 10.1136/amiajnl-2012-001061