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Studies on symptom concordance between patients and their caregivers often use cross-sectional designs, which may fail to capture the longitudinal, dynamic symptom experience. The Behavioral and Environmental Sensing and Intervention for Cancer (BESI-C) is a remote health monitoring system that utilizes smartwatches and ecological momentary assessments (EMAs) to empower patients and caregivers to monitor and manage cancer pain at home. BESI-C collects real-time symptom data in naturalistic settings, enabling longitudinal [...]

School violence risk prevention in the United States relies on manual assessments that are time-consuming and subjective. We developed a machine learning algorithm named Automated RIsk Assessment (ARIA), using natural language processing (NLP) to find linguistic patterns in standardized interview questions that can predict risk of aggression. Our goal was to evaluate the incremental change in performance with the addition of each question to simulate situations where interviews cannot be [...]

Our objective was to determine how social vulnerabilities, broadband access, and rurality relate to telemedicine use across the United States through large-scale analysis of real-world telemedicine data.

To develop an image retrieval pipeline capable of identifying specific series of thoracic aortic computed tomography (CT) scans from a diverse database.

No existing algorithm can reliably identify metastasis from pathology reports across multiple cancer types and the entire US population. In this study, we develop a deep learning model that automatically detects patients with metastatic cancer by using pathology reports from many laboratories and of multiple cancer types.

To determine whether a novel digital tool, the Community Vulnerability Compass (CVC), built using large datasets, can accurately measure neighborhood- and individual-level social determinants of health (SDOH) at scale. Existing SDOH indexes fall short of this dual requirement.

Acute kidney injury (AKI) is common in intensive care unit (ICU) patients and is associated with high mortality, prolonged ICU stays, and increased costs. Early prediction is crucial for timely intervention and improved outcomes. Various prediction models, including machine learning, deep learning, and dynamic prediction frameworks, have been developed, but their modeling approaches, data utilization, and clinical applicability require further investigation. This review comprehensively assesses the modeling methods, data utilization [...]

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that disproportionately affects women and racial/ethnic minority groups. Predicting disease flares is essential for improving patient outcomes, yet few studies integrate both clinical and social determinants of health (SDoH). We therefore developed FLAME (FLAre Machine learning prediction of SLE), a machine learning pipeline that uses electronic health records (EHRs) and contextual-level SDoH to predict 3-month flare risk, emphasizing explainability and fairness.

Recent advancements of Artificial Intelligence (AI) are rapidly transforming clinical research. While this technology offers exciting opportunities, it amplifies existing concerns regarding the need for transparent methodology that fosters patient engagement, and introduces new challenges. PCORI's Improving Methods portfolio has invested in methodological research to enhance rigor and transparency via patient-centered approaches in AI.

To improve the identification of patients with health-related social needs (HRSNs) in the emergency department (ED), we developed and integrated a risk prediction score into an existing Fast Healthcare Interoperability Resources (FHIR)-based clinical decision support (CDS).