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Recent advancements of Artificial Intelligence (AI) are rapidly transforming clinical research. While this technology offers exciting opportunities, it amplifies existing concerns regarding the need for transparent methodology that fosters patient engagement, and introduces new challenges. PCORI's Improving Methods portfolio has invested in methodological research to enhance rigor and transparency via patient-centered approaches in AI.

To evaluate clinical decision support (CDS) of varying complexities and care settings represented using Health Information Technology (HIT) standards-Clinical Quality Language (CQL) for representing clinical logic and Fast Healthcare Interoperability Resources (FHIR) for health information exchange.

Large language models (LLMs) have demonstrated high levels of performance in clinical information extraction compared to rule-based systems and traditional machine-learning approaches, offering scalability, contextualization, and easier deployment. However, most studies rely on proprietary models with privacy concerns and high costs, limiting accessibility. We aim to evaluate 14 publicly available open-source LLMs for extracting clinically relevant findings from free-text echocardiogram reports and examine the feasibility of their implementation in information [...]

Our objective is to compare different pre-training strategies for electronic health record (EHR) foundation models.

Existing ophthalmology studies for clinical phenotypes identification in real-world datasets (RWD) rely exclusively on structured data elements (SDE). We evaluated the performance, generalizability, and fairness of multimodal ensemble models that integrate real-world SDE and free-text data compared to SDE-only models to identify patients with glaucoma.

To address biased representation in Electronic Health Records (EHRs) across subpopulations (SPs), which leads to predictive models underperforming for underrepresented groups, we propose a framework to enhance equitable predictive performance.

Artificial Intelligence (AI) is transforming healthcare by improving diagnostics, treatment recommendations, and resource allocation. However, its implementation also raises ethical concerns, particularly regarding biases in AI algorithms trained on inequitable data, which may reinforce health disparities. This article introduces the AI COmmunity-based Ethical Dialogue and DEcision-making (CODE) framework to embed ethical deliberation into AI development, focusing on Electronic Health Records (EHRs).

Use of secure messaging through the patient portal has increased in recent years. We compile evidence of how patient-initiated secure messaging has been measured, factors associated with use, and effects on individual and organization-level outcomes.

Large language models (LLMs) offer potential in natural language processing tasks in healthcare. Due to the need for high accuracy, understanding their limitations is essential. The purpose of this study was to evaluate the performance of LLMs in classifying radiology reports for the presence of pulmonary embolism (PE) under various conditions, including different prompt designs and data perturbations.

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, with up to 70% of cases remaining undiagnosed. This paper proposes a COPD screening tool based on time-frequency representation features of self-recorded respiratory sounds.