In vitro to in vivo translation of artificial intelligence for clinical use: screening for acute coronary syndrome to identify ST-elevation myocardial infarction.
The integration of predictive models into live clinical care requires scientific testing before implementation to ensure patient safety. We built and technically implemented a model that predicts which patients require an electrocardiogram (ECG) to screen for heart attacks within 10 minutes of their arrival to the Emergency Department. We developed a structured framework for the in vitro to in vivo translation of the model through implementation as clinical decision support [...]
Author(s): Bunney, Gabrielle, Miller, Kate, Graber-Naidich, Anna, Kabeer, Rana, Bloos, Sean M, Wessels, Alexander J, Pasao, Melissa A, Rizvi, Marium, Brown, Ian P, Yiadom, Maame Yaa A B
DOI: 10.1093/jamia/ocaf101