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Immunotherapy has emerged as a promising treatment for advanced non-small cell lung cancer (NSCLC), but accurately predicting which patients will benefit from it remains a major clinical challenge. To address this, we aim to develop a novel multimodal method, DeepAFM, that integrates histopathology, genomic features, and clinical information to predict patient responses to anti-PD-(L)1 immunotherapy.

By October 1, 2024, over 450,000 COVID-19 manuscripts were published, with 10% posted as unreviewed preprints. While they accelerate knowledge sharing, their inconsistent quality complicates systematic studies.

Infections following healthcare-associated interventions drive patient morbidity and mortality, making early detection essential. Traditional predictive models utilize preoperative surgical characteristics. This study evaluated whether integrating postoperative laboratory values and their kinetics could improve outcome prediction.

Systematic reviews in comparative effectiveness research require timely evidence synthesis. With the rapid advancement of medical research, preprint articles play an increasingly important role in accelerating knowledge dissemination. However, as preprint articles are not peer-reviewed before publication, their quality varies significantly, posing challenges for evidence inclusion in systematic reviews.

Clinician implicit bias can impede patient-centered communication, leading to health care inequities. While the field of implicit bias education is evolving with advances in technology, clinicians' perspectives remain underexplored. This study investigated clinicians' perceptions of educational strategies to complement communication feedback technology in the implementation of an implicit bias education intervention.

Pediatric hospital readmissions increase healthcare costs and highlight gaps in care. Social determinants of health (SDOH), such as housing and transportation insecurity, significantly impact outcomes but are underexplored in pediatric populations.

To evaluate ChatGPT's ability to perform thematic analysis of medical Best Practice Advisory (BPA) free-text comments and identify prompt engineering strategies that optimize performance.

Sleep quality critically influences recovery in neurological patients, yet its longitudinal monitoring during hospitalization remains limited. Nursing narrative notes offer an underutilized resource to track sleep trajectories objectively across time.To propose and apply a formal pipeline that integrates structured clinical data and unstructured nursing annotations to monitor sleep trajectories during post-acute inpatient neurorehabilitation, relying exclusively on free-to-use software tools and without increasing nursing workload.A total of 17,039 nighttime nursing annotations [...]

Patient experience mechanisms (e.g., safety netting, patient partnership) are routinely used by health care professionals (HCPs) to support high-quality care. However, there is limited synthesis of these mechanisms across studies, and little is known about how they translate to virtual care.This study aimed to conduct a scoping review to (1) identify mechanisms used by HCPs to enhance patient experience during consultations and (2) to consider how these may be adapted [...]

Anticoagulation decisions in atrial fibrillation (AF) depend on balancing stroke and bleeding risk, often guided by CHA2DS2-VASc (a validated clinical score used to estimate stroke risk in patients with atrial fibrillation) and HAS-BLED (a validated clinical score used to estimate bleeding risk in patients treated with anticoagulation) scores. Manual calculation of these scores can be time-consuming and inconsistently performed.This study evaluated whether implementing real-time, electronic health record (EHR)-integrated alerts in [...]