Extending unbiased stereology of brain ultrastructure to three-dimensional volumes.
Analysis of brain ultrastructure is needed to reveal how neurons communicate with one another via synapses and how disease processes alter this communication. In the past, such analyses have usually been based on single or paired sections obtained by electron microscopy. Reconstruction from multiple serial sections provides a much needed, richer representation of the three-dimensional organization of the brain. This paper introduces a new reconstruction system and new methods for [...]
Author(s): Fiala, J C, Harris, K M
DOI: 10.1136/jamia.2001.0080001