Harnessing the power of large language models for clinical tasks and synthesis of scientific literature.
Author(s): Bakken, Suzanne
DOI: 10.1093/jamia/ocaf071
Author(s): Bakken, Suzanne
DOI: 10.1093/jamia/ocaf071
Congenital heart disease (CHD) patients with single ventricle physiology (SVP) have heterogeneous characteristics that challenge cohort classification. We aim to develop a phenotyping algorithm that accurately identifies SVP patients using electronic health record (EHR) data.
Author(s): Xu, Hang, Renella, Pierangelo, Badiyan, Ramin, Hindosh, Ziad R, Elisarraras, Francisco X, Zhu, Bing, Satou, Gary M, Husain, Majid, Finn, J Paul, Hsu, William, Nguyen, Kim-Lien
DOI: 10.1093/jamiaopen/ooaf035
The objective of the study was to determine, after medication review, the patient risk score threshold that would distinguish between stays with prescriptions triggering pharmacist intervention (PI) and stays with prescriptions not triggering PI.
Author(s): Robert, Laurine, Vidoni, Nathalie, Gérard, Erwin, Chazard, Emmanuel, Odou, Pascal, Rousselière, Chloé, Décaudin, Bertrand
DOI: 10.1093/jamiaopen/ooaf030
This study aims to develop and evaluate an approach using large language models (LLMs) and a knowledge graph to triage patient messages that need emergency care. The goal is to notify patients when their messages indicate an emergency, guiding them to seek immediate help rather than using the patient portal, to improve patient safety.
Author(s): Liu, Siru, Wright, Aileen P, McCoy, Allison B, Huang, Sean S, Steitz, Bryan, Wright, Adam
DOI: 10.1093/jamia/ocaf059
Large language models (LLMs) have shown potential in biomedical applications, leading to efforts to fine-tune them on domain-specific data. However, the effectiveness of this approach remains unclear. This study aims to critically evaluate the performance of biomedically fine-tuned LLMs against their general-purpose counterparts across a range of clinical tasks.
Author(s): Dorfner, Felix J, Dada, Amin, Busch, Felix, Makowski, Marcus R, Han, Tianyu, Truhn, Daniel, Kleesiek, Jens, Sushil, Madhumita, Adams, Lisa C, Bressem, Keno K
DOI: 10.1093/jamia/ocaf045
Diagnosis codes documented in electronic health records (EHR) are often relied upon to clinically phenotype patients for biomedical research. However, these diagnoses can be incomplete and inaccurate, leading to false negatives when searching for patients with phenotypes of interest. This study aims to determine whether PheMAP, a comprehensive knowledgebase integrating multiple clinical terminologies beyond diagnosis to capture phenotypes, can effectively identify patients lacking relevant EHR diagnosis codes.
Author(s): Yan, Chao, Grabowska, Monika E, Thakkar, Rut, Dickson, Alyson L, Embí, Peter J, Feng, QiPing, Denny, Joshua C, Kerchberger, Vern Eric, Malin, Bradley A, Wei, Wei-Qi
DOI: 10.1093/jamia/ocaf055
To develop a corpus annotated for diet-microbiome associations from the biomedical literature and train natural language processing (NLP) models to identify these associations, thereby improving the understanding of their role in health and disease, and supporting personalized nutrition strategies.
Author(s): Hong, Gibong, Hindle, Veronica, Veasley, Nadine M, Holscher, Hannah D, Kilicoglu, Halil
DOI: 10.1093/jamia/ocaf054
Author(s): Layne, Ethan, Cei, Francesco, Cacciamani, Giovanni E
DOI: 10.1093/jamia/ocaf024
The primary objective was to compile a comprehensive list of Logical Observation Identifiers Names and Codes (LOINC) terms that may be associated with patient, healthcare provider, and healthcare facility identifying information.
Author(s): Nourelahi, Mehdi, Sadhu, Eugene M, Samayamuthu, Malarkodi J, Visweswaran, Shyam
DOI: 10.1093/jamia/ocaf061
To develop a continual process for linking more comprehensive external mortality data to electronic health records (EHRs) for a large healthcare system, which can serve as a template for other healthcare systems.
Author(s): Powers, John P, Nandhakumar, Samyuktha, Dard, Sofia Z, Kovach, Paul, Leese, Peter J
DOI: 10.1093/jamia/ocaf060