Precision medicine informatics.
Author(s): Frey, Lewis J, Bernstam, Elmer V, Denny, Joshua C
DOI: 10.1093/jamia/ocw053
Author(s): Frey, Lewis J, Bernstam, Elmer V, Denny, Joshua C
DOI: 10.1093/jamia/ocw053
Since the launch of the clinical informatics subspecialty for physicians in 2013, over 1100 physicians have used the practice and education pathways to become board-certified in clinical informatics. Starting in 2018, only physicians who have completed a 2-year clinical informatics fellowship program accredited by the Accreditation Council on Graduate Medical Education will be eligible to take the board exam. The purpose of this viewpoint piece is to describe the collective [...]
Author(s): Longhurst, Christopher A, Pageler, Natalie M, Palma, Jonathan P, Finnell, John T, Levy, Bruce P, Yackel, Thomas R, Mohan, Vishnu, Hersh, William R
DOI: 10.1093/jamia/ocv209
Standards requiring education in informatics in pharmacy curricula were introduced in the last 10 years by the Accreditation Council for Pharmacy Education. Mirroring difficulties faced by other health professions educators, implementation of these requirements remains fragmented and somewhat limited across colleges of pharmacy in the US. Clinical practice and workforce metrics underline a pronounced need for clinicians with varying competencies in health informatics. In response to these challenges, a multitiered [...]
Author(s): Breeden, Elizabeth A, Clauson, Kevin A
DOI: 10.1093/jamia/ocw023
(1) To develop an automated algorithm to predict a patient's response (ie, if the patient agrees or declines) before he/she is approached for a clinical trial invitation; (2) to assess the algorithm performance and the predictors on real-world patient recruitment data for a diverse set of clinical trials in a pediatric emergency department; and (3) to identify directions for future studies in predicting patients' participation response.
Author(s): Ni, Yizhao, Beck, Andrew F, Taylor, Regina, Dyas, Jenna, Solti, Imre, Grupp-Phelan, Jacqueline, Dexheimer, Judith W
DOI: 10.1093/jamia/ocv216
The recent announcement of the Precision Medicine Initiative by President Obama has brought precision medicine (PM) to the forefront for healthcare providers, researchers, regulators, innovators, and funders alike. As technologies continue to evolve and datasets grow in magnitude, a strong computational infrastructure will be essential to realize PM's vision of improved healthcare derived from personal data. In addition, informatics research and innovation affords a tremendous opportunity to drive the science [...]
Author(s): Tenenbaum, Jessica D, Avillach, Paul, Benham-Hutchins, Marge, Breitenstein, Matthew K, Crowgey, Erin L, Hoffman, Mark A, Jiang, Xia, Madhavan, Subha, Mattison, John E, Nagarajan, Radhakrishnan, Ray, Bisakha, Shin, Dmitriy, Visweswaran, Shyam, Zhao, Zhongming, Freimuth, Robert R
DOI: 10.1093/jamia/ocv213
Development of computational approaches and tools to effectively integrate multidomain data is urgently needed for the development of newly targeted cancer therapeutics.
Author(s): Cheng, Feixiong, Zhao, Junfei, Fooksa, Michaela, Zhao, Zhongming
DOI: 10.1093/jamia/ocw007
As targeted cancer therapies and molecular profiling become widespread, the era of "precision oncology" is at hand. However, cancer genomes are complex, making mutation-specific outcomes difficult to track. We created a proof-of-principle, CUSTOM-SEQ: Continuously Updating System for Tracking Outcome by Mutation, to Support Evidence-based Querying, to automatically calculate and display mutation-specific survival statistics from electronic health record data.
Author(s): Warner, Jeremy L, Wang, Lucy, Pao, William, Sosman, Jeffrey A, Atreya, Ravi V, Carney, Pam, Levy, Mia A
DOI: 10.1093/jamia/ocw008
Precision medicine approaches disease treatment and prevention by taking patients' individual variability in genes, environment, and lifestyle into account. Although the ideas underlying precision medicine are not new, opportunities for its more widespread use in practice have been enhanced by the development of large-scale databases, new methods for categorizing and representing patients, and computational tools for analyzing large datasets. New research methods may create uncertainty for both healthcare professionals and [...]
Author(s): Adams, Samantha A, Petersen, Carolyn
DOI: 10.1093/jamia/ocv215
To understand how consumer questions on online resources differ from questions asked by professionals, and how such consumer questions differ across resources.
Author(s): Roberts, Kirk, Demner-Fushman, Dina
DOI: 10.1093/jamia/ocw024
Increasing access to biomedical informatics experiences is a significant need as the field continues to face workforce challenges. Looking beyond traditional medical school and graduate school pathways into the field is crucial for expanding the number of individuals and increasing diversity in the field. This case report provides an overview of the development and initial implementation of the American Medical Informatics Association (AMIA) High School Scholars Program. Initiated in 2014 [...]
Author(s): Unertl, Kim M, Finnell, John T, Sarkar, Indra Neil
DOI: 10.1093/jamia/ocw036