Illustrating potential effects of alternate control populations on real-world evidence-based statistical analyses.
Case-control study designs are commonly used in retrospective analyses of real-world evidence (RWE). Due to the increasingly wide availability of RWE, it can be difficult to determine whether findings are robust or the result of testing multiple hypotheses.
Author(s): Huang, Yidi, Yuan, William, Kohane, Isaac S, Beaulieu-Jones, Brett K
DOI: 10.1093/jamiaopen/ooab045