Design and analysis of controlled trials in naturally clustered environments: implications for medical informatics.
In medical informatics research, study questions frequently involve individuals who are grouped into clusters. For example, an intervention may be aimed at a clinician (who treats a cluster of patients) with the intention of improving the health of individual patients. Correlation among individuals within a cluster can lead to incorrect estimates of the sample size required to detect an effect and inappropriate estimates of the confidence intervals and the statistical [...]
Author(s): Chuang, Jen-Hsiang, Hripcsak, George, Heitjan, Daniel F
DOI: 10.1197/jamia.m0997