An outcome model approach to transporting a randomized controlled trial results to a target population.
Participants enrolled into randomized controlled trials (RCTs) often do not reflect real-world populations. Previous research in how best to transport RCT results to target populations has focused on weighting RCT data to look like the target data. Simulation work, however, has suggested that an outcome model approach may be preferable. Here, we describe such an approach using source data from the 2 × 2 factorial NAVIGATOR (Nateglinide And Valsartan in Impaired Glucose [...]
Author(s): Goldstein, Benjamin A, Phelan, Matthew, Pagidipati, Neha J, Holman, Rury R, Pencina, Michael J, Stuart, Elizabeth A
DOI: 10.1093/jamia/ocy188