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To compare Observational Medical Outcomes Partnership (OMOP) Logical Observation Identifiers Names and Codes (LOINC) and Veterans Aging Cohort Study (VACS) methods for extracting laboratory chemistry data from Veterans Health Administration (VA) electronic health records (EHR).

Federated analysis is a method that allows data analysis to be performed on similar datasets without exchanging any data, thus facilitating international research collaboration while adhering to strict privacy laws. This study aimed to evaluate the feasibility of using federated analysis to benchmark mortality in 2 critical care quality registry databases converted to the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM), describing challenges to and recommendations for performing [...]

To determine whether a novel digital tool, the Community Vulnerability Compass (CVC), built using large datasets, can accurately measure neighborhood- and individual-level social determinants of health (SDOH) at scale. Existing SDOH indexes fall short of this dual requirement.

Conversational Health Agents (CHAs) are interactive systems providing healthcare services, such as assistance and diagnosis. Current CHAs, especially those utilizing Large Language Models (LLMs), primarily focus on conversation aspects. However, they offer limited agent capabilities, specifically needing more multistep problem-solving, personalized conversations, and multimodal data analysis. We aim to overcome these limitations.

Our objective was to determine how social vulnerabilities, broadband access, and rurality relate to telemedicine use across the United States through large-scale analysis of real-world telemedicine data.

Recent advancements of Artificial Intelligence (AI) are rapidly transforming clinical research. While this technology offers exciting opportunities, it amplifies existing concerns regarding the need for transparent methodology that fosters patient engagement, and introduces new challenges. PCORI's Improving Methods portfolio has invested in methodological research to enhance rigor and transparency via patient-centered approaches in AI.

Mobile and ubiquitous devices enable health data collection "in a free-living environment" to support applications such as remote patient monitoring and adaptive digital interventions using machine learning (ML). Despite their potential, significant data collection challenges persist, including issues related to user compliance with reporting data, passive data consistency, and authorization. This scoping review identifies and analyzes these challenges, focusing on barriers to effective data collection.

To develop an image retrieval pipeline capable of identifying specific series of thoracic aortic computed tomography (CT) scans from a diverse database.

To assess the calibration of 9 large language models (LLMs) within biomedical natural language processing (BioNLP) tasks, furthering understanding of trustworthiness and reliability in real-world settings.

We aim to leverage more comprehensive phenotypic and genotypic clinical data to enhance the treatment response predictions.