Clinical Implementation of Pharmacogenetics-Based Machine Learning Clinical Decision Support Systems: A Scoping Review.
BACKGROUND: Pharmacogenetics is increasingly recognized as essential for optimizing drug therapy and reducing preventable adverse drug events. However, applying pharmacogenetic data in real-world clinical decisions remains challenging. Traditional rule-based clinical decision support systems often fall short. Machine learning-based clinical decision support systems offer a more dynamic solution, combining pharmacogenetic variants, patient-specific clinical data, medication history, and guidelines to generate personalized treatment recommendations.
Author(s): Taylor, April D, Goodloe, Robert J, Rosenman, Marc B, Fulton, Cathy R
DOI: 10.1055/a-2927-0698