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Members of the Education Working Group advance the teaching of informatics as a discipline and promote clinical transformation through the integration of health information technology into the curriculum of health professionals. The Education Working Group is engaged in research efforts aimed at understanding the present climate and improving informatics education.

The mission is sharing of informatics best practices in resource-constrained countries.

Maturity models are instruments to define and facilitate organization management with regard to a particular function or behavior. Maturity models allow organizational self-assessment based on multiple axes, including organizational culture, process standardization and technology to arrive at a final overall maturity level, and also allowing organizations to identify areas of weakness.

The goal of the Intensive Care Informatics Working Group is to improve outcomes of critically ill and injured patients with the help of medical informatics.

Knowledge Representation furthers research on formalisms and tools for semantically precise and computable knowledge representation in relation to biomedicine.

Knowledge Discovery and Data Mining focuses on the process of extracting meaningful patterns from biomedical data (knowledge discovery), using automated computational and statistical tools and techniques on large datasets (data mining).

The goals of the AMIA LHS-WG are to build a community of LHS practitioners and researchers in AMIA, foster LHS research and applications, and establish connections among the group from different scientific backgrounds including outside of informatics, and countries.

MHI-WG aims to promote and facilitate opportunities to develop and apply informatics methods and approaches in the context of mental health research and care.

Nursing Informatics is the "science and practice (that) integrates nursing, its information and knowledge, with management of information and communication technologies to promote the health of people, families, and communities worldwide."

The mission of the People and Organizational Issues-Evaluation (POI-Eval) Working Group is to study the interactions between people and technology, including designing, implementing, evaluating, and optimizing safe and usable health information systems and technology.