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To reflect on the achievements of the Agency for Healthcare Research and Quality's (AHRQ) Digital Healthcare Research Program over the past 20 years, evaluate its impact on US healthcare quality and safety, and outline current and future priorities for digital healthcare research and innovation.

To explore home healthcare (HHC) clinicians' needs for Clinical Decision Support Systems (CDSS) information delivery for early risk warning within HHC workflows.

Examine electronic health record (EHR) use and factors contributing to documentation burden in acute and critical care nurses.

The retinal age gap (RAG) is emerging as a potential biomarker for various diseases of the human body, yet its utility depends on machine learning models capable of accurately predicting biological retinal age from fundus images. However, training generalizable models is hindered by potential shortages of diverse training data. To overcome these obstacles, this work develops a novel and computationally efficient distributed learning framework for retinal age prediction.

 N-of-1 trials have emerged as a personalized approach to patient-centered care, where patients can compare evidence-based treatments using their own data. However, little is known about optimal methods to present individual-level data from medication-related N-of-1 trials to patients to promote decision-making.

 High-value care aims to enhance meaningful patient outcomes while reducing costs and is accelerated by curating data across health care systems through common data models (CDMs), such as Observational Medical Outcomes Partnership (OMOP). Meaningful patient outcomes, such as physical function, must be included in these CDMs. However, the extent to which physical therapy assessments are covered in the OMOP CDM is unclear.

Large language models (LLMs) can assist providers in drafting responses to patient inquiries. We examined a prompt engineering strategy to draft responses for providers in the electronic health record. The aim was to evaluate the change in usability after prompt engineering.

 We developed and implemented a customized internal clinical informatics (CI) curriculum for the UC Irvine CI Fellowship program. The goal was to transition from an externally sourced curriculum to a more focused, internally developed program, aligning with feedback from early fellows and the evolving practical needs of clinical informatics. By designing this curriculum in-house, we sought to provide a more efficient, cost-effective, and relevant educational experience for fellows.

 Social media networks have been found to provide emotional, instrumental, and social support, which may contribute to improved adherence to postbariatric surgery care recommendations.

 Interruptive alerts are known to be associated with clinician alert fatigue, and poorly performing alerts should be evaluated for alternative solutions. An interruptive alert to remind clinicians about a required peripherally inserted central catheter (PICC) dressing change within the first 48 hours after placement resulted in 617 firings in a 6-month period with only 11 (1.7%) actions taken from the alert.