ATLAS: an automated association test using probabilistically linked health records with application to genetic studies.
Large amounts of health data are becoming available for biomedical research. Synthesizing information across databases may capture more comprehensive pictures of patient health and enable novel research studies. When no gold standard mappings between patient records are available, researchers may probabilistically link records from separate databases and analyze the linked data. However, previous linked data inference methods are constrained to certain linkage settings and exhibit low power. Here, we present [...]
Author(s): Zhang, Harrison G, Hejblum, Boris P, Weber, Griffin M, Palmer, Nathan P, Churchill, Susanne E, Szolovits, Peter, Murphy, Shawn N, Liao, Katherine P, Kohane, Isaac S, Cai, Tianxi
DOI: 10.1093/jamia/ocab187