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To systematically examine different clinical data modalities in large language models (LLMs) and multimodal large language models (MLLMs), and to quantify the contribution of data modalities in early inpatient risk prediction and decision support tasks.

Human Factors (HF) principles are essential for safe and effective clinical decision support (CDS), yet existing guidance is fragmented and rarely evaluated in real world settings. A novel, evidence-based, vendor-agnostic HF-informed guideline was developed to address this gap. This study evaluated its perceived usefulness, usability, and impact on CDS design and optimization.

Clinical AI systems and models increasingly need traceable documentation that makes intended use, performance evidence, transparency, and lifecycle status explicit, yet existing model cards, datasheets, reporting guidelines, and other documentation approaches do not consistently bring together structured clinical fields, vocabulary-linked cohort descriptions, structured performance reporting, and governed documentation history. We introduce Structured, Meaningful, Auditable, Responsible, and Transparent (SMART), a framework that adapts the model card concept into structured, lifecycle-aware documentation [...]

Information extraction (IE) from clinical texts has advanced rapidly with recent advances in natural language processing, particularly the advent of large language models (LLMs). However, inconsistent and incomplete reporting of methodologies limits reproducibility, comparability, and clinical translation. We aimed to develop a consensus-based reporting guideline tailored to clinical IE studies.

This study aimed to identify trajectories of multimorbidity following acute myocardial infarction (AMI), using explainable temporal machine-learning methods, and assess their clinical, prognostic, and biological significance.

The potential of "big data" in health research remains largely untapped, particularly concerning real-world data sources such as administrative health data and electronic medical records. While healthcare insurance claims data have been essential for assessing medication safety and effectiveness within indicated patient populations, exploring broader drug-outcome associations could uncover significant insights.

To develop and systematically compare a human-led and LLM-assisted hybrid deductive-inductive workflow for qualitative analyses.

Accurate citation of relevant publications is essential for scientific integrity in biomedical research. Large language models (LLMs) excel at text generation but often hallucinate fabricated or inaccurate citations. Retrieval-augmented generation (RAG) can mitigate these errors, yet current approaches lack semantic precision in evidence retrieval. This study aims to develop a domain-specific RAG system for reliable, context-specific biomedical citation recommendations.

Large-scale propensity score (LSPS) models are increasingly used to control confounding in observational studies, but their reliability in small-sample settings is unclear. Small samples can limit a study's ability to estimate propensity scores accurately and achieve adequate covariate balance, raising concerns about insufficient confounding adjustment. Resulting in small datasets being excluded, despite potentially containing valid information.