Large-scale evidence generation and evaluation across a network of databases (LEGEND): assessing validity using hypertension as a case study.
To demonstrate the application of the Large-scale Evidence Generation and Evaluation across a Network of Databases (LEGEND) principles described in our companion article to hypertension treatments and assess internal and external validity of the generated evidence.
Author(s): Schuemie, Martijn J, Ryan, Patrick B, Pratt, Nicole, Chen, RuiJun, You, Seng Chan, Krumholz, Harlan M, Madigan, David, Hripcsak, George, Suchard, Marc A
DOI: 10.1093/jamia/ocaa124