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This study aimed to characterize patterns of digital health technology (DHT) use and examine the relationships between multimorbidity, DHT adoption, and user-reported frustration, with a focus on identifying socioeconomic and phenotypic determinants of digital health burden.

We aimed to develop a data model and a natural language processing (NLP) pipeline for representing physical activity (PA) in Electronic Health Records (EHRs), and to evaluate transformer- and Large Language Model (LLM)-based classifiers for sentence-level PA attribute classification.

To evaluate the clinical applications and translation readiness of model-based synthetic tabular data in healthcare, and identify gaps in governance reporting that may hinder translation.

Computable phenotypes derived from electronic health records (EHRs) are central to clinical research and quality reporting. Although large language models (LLMs) can extract clinically rich information from unstructured notes, routine application to all patients is computationally expensive. We evaluated whether uncertainty-guided selective use of LLMs can improve phenotyping accuracy while preserving scalability.

Patients with rare diseases often face long delays before receiving a diagnosis. Using electronic health records for automated phenotyping and diagnosis of rare diseases is a promising approach but can be challenging because critical information is often recorded in unstructured notes rather than structured fields. This systematic review synthesizes the current literature applying natural language processing (NLP) and large language models (LLMs) for rare disease phenotyping and diagnosis from clinical [...]

To examine real-world barriers to implementing federated learning in healthcare and highlight the organizational, regulatory, and socio-technical factors often overlooked in technical research.

We report on findings from a meeting convened by the American College of Medical Informatics (ACMI) to characterize aspects of the patient experience that could be improved using informatics.

Home healthcare (HHC) clinical notes contain critical infection indicators that clinicians need in structured "indicator + context" pairs. Data sparsity and limited computing resources hinder automated extraction in decentralized HHC settings. This study developed and evaluated a resource-efficient pipeline using instruction-tuned, moderate-sized large language models (LLMs) to address these barriers. To address the data sparsity challenge, we also assessed the impact of a targeted LLM-based data augmentation strategy.

Leveraging routine electronic health records (EHR) for dementia detection is a growing field, but quality and clinical utility of existing models are unclear. This systematic review aimed to evaluate performance, methodological quality, and risk of bias of EHR-based dementia prediction models.

The increasing use of machine learning (ML) in clinical care makes fairness a central issue. Fairness, defined as the absence of disparities across individuals or subgroups, shares several parallels with concepts in clinical epidemiology. The objective was to apply clinical epidemiology frameworks to the evaluation of ML fairness, both to enhance understanding of these concepts and to strengthen fairness assessments.