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To develop an electronic health record (EHR)-based multimorbidity-weighted index (eMWI) using computable phenotypes mapped to the Observational Medical Outcomes Partnership (OMOP) common data model and previously validated physical functioning-based condition weights.

Cardiac surgeries are associated with a range of serious postoperative complications, and current predictive models often rely on static summaries of preoperative and intraoperative data compiled after the case. Such development limits their utility in real-time clinical settings. To address this challenge, we developed TE-Transformer, an end-to-end deep learning framework that continuously ingests heterogeneous electronic health record (EHR) data-including preoperative variables, high-frequency vital signs, medication administration records, and brief surgical [...]

Older adults face disproportionate risk of diagnostic errors in primary care, yet effective diagnostic decision support systems (DDSSs) remain lacking. Existing artificial intelligence (AI)-based DDSSs rely on gold-standard labels infeasible to obtain, have narrow diagnostic scope, and fail to reflect real-world uncertainty. We developed and validated a deep learning DDSS using imitation learning and collective clinician intelligence to generate diagnostic and order recommendations.

To demonstrate a replicable in-house framework for evaluating ambient digital scribe (ADS) systems and, applying it, to assess 3 commercial systems and examine alignment between clinician Likert ratings and a manual transcript-level error audit.

Pregnant and breastfeeding women, along with children, represent populations persistently underrepresented in clinical research, leading to uncertainty in clinical decision-making. This study investigated the landscape of pharmacology research concerning pharmacokinetics (PK), pharmaco-epidemiology (PE), and clinical trials (CT) within maternal and pediatric patient populations.

Artificial intelligence (AI) adoption in global health informatics is accelerating, yet scaling, sustainability, equity, and environmental challenges limit impact, particularly in Low and Middle Income Countries (LMICs).

Modern biomedical data ecosystems increasingly rely on global cloud platforms to coordinate access to large-scale genomic and clinical datasets. However, operational governance remains largely investigator-centric, shifting the responsibility for complex security, compliance, and infrastructure management to individual laboratories. As data volumes and regulatory requirements expand, this approach fails to scale across the research enterprise. This disjointed approach creates a substantial governance burden and can slow down scientific progress. In centralized [...]

To develop and validate an open-source evaluation framework that assesses clinical AI diagnostic systems across multiple clinically relevant dimensions (accuracy, cost, time, invasiveness, physician effort, and safety behaviors), addressing the limitations of accuracy-only benchmarks.

To examine the characteristics, scope, and thematic content of institutional and program-level academic artificial intelligence (AI) policies and guidance documents used by CAHIIM-accredited Health Informatics (HI) and Health Information Management (HIM) master's programs in the United States.

To evaluate whether retrieval-augmented generation (RAG) can serve as an efficient alternative to long-context prompting for clinical reasoning over electronic health records (EHRs).