HTI-4 Policy Summary: Implications for Electronic Prescribing and Prior Authorization

The HTI-4 Final Rule, released July 31, 2025, introduces new requirements aimed at reducing administrative burden and improving transparency in patient care. Key changes include real-time access to prescription drug costs, automated prior authorization through standardized APIs, and integrated clinical decision support within EHRs. These updates, effective October 1, 2025, are intended to give clinicians better tools at the point of care while advancing interoperability across health IT systems. AMIA recommendations aligned with some provisions, including support for updated FHIR standards, RxNorm, and NCPDP SCRIPT, ensuring policies align with practical needs in clinical workflows.